Ambient air pollution and adult asthma incidence in six European cohorts (ESCAPE).

TitleAmbient air pollution and adult asthma incidence in six European cohorts (ESCAPE).
Publication TypeJournal Article
Year of Publication2015
AuthorsJacquemin B, Siroux V, Sanchez M, Carsin A-E, Schikowski T, Adam M, Bellisario V, Buschka A, Bono R, Brunekreef B, Cai Y, Cirach M, Clavel-Chapelon F, Declercq C, de Marco R, de Nazelle A, Ducret-Stich RE, Ferretti VValeria, Gerbase MW, Hardy R, Heinrich J, Janson C, Jarvis D, Kanaani ZAl, Keidel D, Kuh D, Le Moual N, Nieuwenhuijsen MJ, Marcon A, Modig L, Pin I, Rochat T, Schindler C, Sugiri D, Stempfelet M, Temam S, Tsai M-Y, Varraso R, Vienneau D, Vierkötter A, Hansell AL, Krämer U, Probst-Hensch NM, Sunyer J, Künzli N, Kauffmann F
JournalEnviron Health Perspect
Volume123
Issue6
Pagination613-21
Date Published2015 Jun
ISSN1552-9924
KeywordsAdult, Aged, Aged, 80 and over, Air Pollutants, Asthma, Environmental Exposure, Europe, Female, Follow-Up Studies, Humans, Incidence, Logistic Models, Male, Middle Aged, Nitrogen Oxides, Particulate Matter, Prospective Studies, Young Adult
Abstract

BACKGROUND: Short-term exposure to air pollution has adverse effects among patients with asthma, but whether long-term exposure to air pollution is a cause of adult-onset asthma is unclear.

OBJECTIVE: We aimed to investigate the association between air pollution and adult onset asthma.

METHODS: Asthma incidence was prospectively assessed in six European cohorts. Exposures studied were annual average concentrations at home addresses for nitrogen oxides assessed for 23,704 participants (including 1,257 incident cases) and particulate matter (PM) assessed for 17,909 participants through ESCAPE land-use regression models and traffic exposure indicators. Meta-analyses of cohort-specific logistic regression on asthma incidence were performed. Models were adjusted for age, sex, overweight, education, and smoking and included city/area within each cohort as a random effect.

RESULTS: In this longitudinal analysis, asthma incidence was positively, but not significantly, associated with all exposure metrics, except for PMcoarse. Positive associations of borderline significance were observed for nitrogen dioxide [adjusted odds ratio (OR) = 1.10; 95% CI: 0.99, 1.21 per 10 μg/m3; p = 0.10] and nitrogen oxides (adjusted OR = 1.04; 95% CI: 0.99, 1.08 per 20 μg/m3; p = 0.08). Nonsignificant positive associations were estimated for PM10 (adjusted OR = 1.04; 95% CI: 0.88, 1.23 per 10 μg/m3), PM2.5 (adjusted OR = 1.04; 95% CI: 0.88, 1.23 per 5 μg/m3), PM2.5absorbance (adjusted OR = 1.06; 95% CI: 0.95, 1.19 per 10-5/m), traffic load (adjusted OR = 1.10; 95% CI: 0.93, 1.30 per 4 million vehicles × meters/day on major roads in a 100-m buffer), and traffic intensity (adjusted OR = 1.10; 95% CI: 0.93, 1.30 per 5,000 vehicles/day on the nearest road). A nonsignificant negative association was estimated for PMcoarse (adjusted OR = 0.98; 95% CI: 0.87, 1.14 per 5 μg/m3).

CONCLUSIONS: Results suggest a deleterious effect of ambient air pollution on asthma incidence in adults. Further research with improved personal-level exposure assessment (vs. residential exposure assessment only) and phenotypic characterization is needed.

DOI10.1289/ehp.1408206
Alternate JournalEnviron. Health Perspect.
Full Text
PubMed ID25712593
PubMed Central IDPMC4455584
Grant ListMC_UU_12019/1 / / Medical Research Council / United Kingdom
MC_UU_12019/2 / / Medical Research Council / United Kingdom
MR/L01341X/1 / / Medical Research Council / United Kingdom